Wednesday, September 1, 2010

Living to 1,000

http://www.guardian.co.uk/science/aubrey-de-grey
http://www.guardian.co.uk/technology/2010/aug/01/aubrey-de-grey-ageing-research

Aubrey de Grey: We don't have to get sick as we get older
If we can stop the physical deterioration that comes with age, molecular biologist Aubrey de Grey sees no reason why human beings shouldn't live to be 1,000
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Caspar Llewellyn Smith
The Observer, Sunday 1 August 2010
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Good innings: Aubrey de Grey wants to help people live to a very ripe old age. Photograph: Roland Kemp / Rex Features
With his beard and robust opinions, there's something of the Old Testament prophet about Aubrey de Grey. But the 47-year-old gerontologist (who studies the process of ageing) says his belief that he might live to the very ripe old age of 1,000 is founded not on faith but science. De Grey studied computer science at Cambridge University, but became interested in the problem of ageing more than a decade ago and is the co-founder of the Sens (Strategies for Engineered Negligible Senescence) Foundation, a non-profit organisation based in the US.

What's so wrong with getting old?

It is simply that people get sick when they get older. I don't often meet people who want to suffer cardiovascular disease or whatever, and we get those things as a result of the lifelong accumulation of various types of molecular and cellular damage. This is harmless at low levels but eventually it causes the diseases and disabilities of old age – which most people don't think are any fun.

Is this the biggest health crisis facing the world?

Absolutely. If we look at the industrialised world, basically 90% of all deaths are caused by ageing. They are deaths from causes that affect older people and don't affect young adults. And if we look at the whole world, then the number of deaths that occur each day is roughly 150,000 and about two-thirds of them are because of ageing.

Why does the world not recognise this?

People have been trying to claim that we can defeat ageing since the dawn of time, and they haven't been terribly successful; there is a tendency to think there is some sort of inevitability about ageing – it somehow transcends our technological abilities in principle, which is complete nonsense.

And when people have made their peace with this ghastly thing that is going to happen to them at some time in the distant future, they tend to be rather reluctant to re-engage the question when someone comes along with a new idea.

Is it that our bodies just stop being so proactive about living?

Basically, the body does have a vast amount of inbuilt anti-ageing machinery; it's just not 100% comprehensive, so it allows a small number of different types of molecular and cellular damage to happen and accumulate. The body does try as hard as it can to fight these things but it is a losing battle. So we are not going to be able to do anything significant about ageing without hi-tech intervention – which is what I'm working on.

Ageing involves the process of metabolism, and then deterioration, and then pathology – is that right?

Basically, that's right. Metabolism involves a vastly complicated network of biochemical and cellular processes that are linked and that succeed in keeping us alive for as long as they do, but they have these side effects.

The side-effects start even before we are born, they go on throughout life and they are manifested as, for example, the accumulation of various types of molecular garbage inside cells and outside cells, or simply as cells dying and not being automatically replaced by the division of other cells. Gradually those changes at the molecular and cellular level accumulate and accumulate and eventually they start to get in the way of metabolism, and that's where pathology comes.

You've identified seven particular areas of cellular decay that might be combated. Can you give examples?

I just mentioned cells dying and not being automatically replaced, that's one. Another is cells not dying when they ought to – certain types of cells are supposed to turn over and sometimes they lose the ability to respond to signals that tell them to die.

A third is cells dividing too much – they may be dying when they are supposed to but dividing too much, and that is what cancer is.

We've known what causes cancer for some time but we are a long way from being able to cure it, aren't we?

I certainly don't claim that any of this is easy. Some of it is easier – but I've always viewed cancer as the single hardest aspect of ageing to fix.

You've talked about enriching people's lives, but isn't it the very fact of death that gives our lives meaning?

That's nonsense. The fact is, people don't want to get sick. I'm just a practical guy. I don't want to get sick and I don't want you to get sick and that's what this is all about. I don't work on longevity, I work on keeping people healthy. The only difference between my work and the work of the whole medical profession is that I think we're in striking distance of keeping people so healthy that at 90 they'll carry on waking up in the same physical state as they were at the age of 30, and their probability of not waking up one morning will be no higher than it was at the age of 30.

You've said you think the first person to live to 1,000 may already be alive. Could that person be you?

It's conceivable that people in my age bracket, their 40s, are young enough to benefit from these therapies. I'd give it a 30% or 40% chance. But that is not why I do this – I do this because I'm interested in saving 100,000 lives a day.

Can the planet cope with people living so long?

That's to do with the balance of birth and death rates. It didn't take us too long to lower the birth rate after we more or less eliminated infant mortality 100 or 150 years ago. I don't see that it's sensible to regard the risk of a population spike as a reason not to give people the best healthcare that we can.

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Synchronium
1 August 2010 12:23AM

I once wrote an essay on the ethics of living forever. The more I thought about it, the more it seemed like a bad idea.

Here's that essay: http://www.synchronium.net/2008/11/18/living-forever-is-it-really-worth-it/

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Zadokk
1 August 2010 12:50AM

I don't think your essay can make the conclusion that it is a bad idea. I would agree that it is a precarious situation. After all, the idea of immortality is associated historically with Gods and most recently with nefarious AI robots so we all have a right to be concerned with the amount of power associated with it.

Dystopian speculations aside, the idea of longevity and life extension is certainly a good thing. Most of us value life and we especially value youth. Ageing is considered to be 'natural' but that doesn't mean that it is necessarily good or the 'right' way of living life, JS Mill told us that over a hundred years ago. In fact, postponing death is something that our genes have programmed us to do. We try to avoid death as much as possible everyday whether through instinctive reactions (e.g. dodging out the way of oncoming traffic) or complex rational decisions (e.g. choosing a private pension scheme).

Life is valuable and furthermore our individual lives are especially valuable to us. Many speculate (with good reason) that we are steadily approaching a technological singularity. This will no doubt bring with it existential risks that we are yet to truly understand. Nick Bostrom was recently in the press and his views got a re-airing. They are worth reading. But we should not be afraid of this coming change. We should embrace it.

I mentioned immortality right at the start, perhaps I misspoke. Life extension is just that, extension. It's about having control over one's body and deciding when it is one time's time to die. Perhaps we will get bored the longer we live and maybe at the age of 1,003 we will decide we have had enough. It is why research like this requires a new morality and a new approach to what life and death are.

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Zadokk
1 August 2010 12:52AM

I should point out that the first paragraph or my previous comment was aimed at Synchronium's self-promotion, not De Grey.

Best of luck to SENS.

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DavidNcUsa
1 August 2010 1:15AM

It is fairly clear that we are on the edge of a tranformation that will turn what has been the province of science fiction into science. The exact timing and content will only be known when it actually happens. But we are likely to achieve a more or less complete understanding of our biology in chemical terms. We are also likely to achieve the ability to modify it as we wish if we chose to do it. The time frame is clearly more than ten years and less than a thousand years. The current century is a pretty good ball park guess. It is reasonable to expext that this event will pose large problems for human beings and hard to predict what we (probably not me since I am old enough to escape it) will do with our new knowledge and powers.

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adundeemonkey
1 August 2010 1:21AM

I want to live forever, but only as long as i dont have to see all those that i love around me die.

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farfrom
1 August 2010 1:49AM

If only we could live longer and combine the energy and enthusiasm of youth with the experience and wisdom of age.
We just don't live long enough . , though we do live longer than most other large animals.

Even if there is reincarnation there would be amnesia.

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symmetric1
1 August 2010 1:56AM

@Synchronium I've noticed those who are against extended life spans are usually young, unhappy, or religious (and think they will live forever anyway).

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icurahuman2
1 August 2010 1:57AM

Humans are the only creatures that are so aware of their mortality that they are taught about death as soon as they are old enough to communicate. This knowledge effects our psychological health and personal behaviour unto the grave, and, is the cause of all religious motivation, reckless endeavour and subjective reasoning.

Without a religion, or a developed philosophy of life, procreation would not continue the species line; humans would shun bearing children as their children's lives must ultimately end in tragedy - this is the hidden reason you find so many childless couples among the intelligensia. The same reasoning applies to keeping pets, who usually live far shorter lives than humans; investing empathy in an animal that one day must die is setting oneself up for an emotionally damaging future event.

That we exist but for a few moments against the vastness of time leads many to search for the immortality we all deeply crave, and religious faith, though probably the most effective, is not the only measure of immortality we can recognise or attain. Celebrity is one way to leave an indelible mark that may extend the life of an individual, though immortality as such relies on the belief that the species will survive it's own plague behaviour.

I suggest that everything that has ever existed always will exist, and that the place where this immortality lives is the set-in-concrete position it takes in time. I also suggest that time is only relative to the perceptions of the perceiver and that when that perception ends, at the end of life, it merely begins anew. Should reality be affected by this re-invented perception to the point of an alteration, then multiple and infinite realities, and lives, would be the result.. Quantum mechanics, anyone?

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Knowles2
1 August 2010 2:00AM

Well I do not want to live forever.

Just long enough to do everything I want to do in life, an that a lot of stuff, I mean being able to stand on mars will not happen in my normal human life span or walking on the moon.
May be a thousand years will cover it or may be it will not but eventually I think I would like to find out what lay beyond death, but then again that does scare the hell out me to. I do not know I would like to imagine eventually we would be allow to choose when we are ready to take that path.

I am not sure whether we will come up with a immortality drug any time soon or in my time. I just hope that as a species where a individual can live forever we will still have the drive an ambition to keep evolving to keep pushing towards new technology an discover new wonders in our universe.

It be rather boring to to live forever an only have earth to explore, eventually you would run out of things to do an get bored.

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Basingstoke
1 August 2010 2:04AM

I just find Aubrey de Grey a rather ridiculous attention seeker, who is probably more interested in being famous than in doing science.
He has not discovered or invented anything that could actually help us to live longer, so what exactly is the point of him?

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farfrom
1 August 2010 2:09AM

What exactly is the point of any of us,including you Basingstoke

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rpclarkeuk
1 August 2010 2:14AM

Fifteen years ago I explained that the brain eventually runs out of memory storage space, "Does longer-term memory storage never become overloaded, and would such overload cause Alzheimer's disease and other dementia?"
http://www.ncbi.nlm.nih.gov/pubmed/11058422.
Of course it's much more profitable to research the non-existent cure than the proof it is impossible.
Yet no challenge has been made to the theory.
I subsequently enhanced the theory with an explanation of how there is another, prinicipal overloading within neurons (not got round to publishing as I am very ill). Basically the human mind does not have room for a 1000 years of experience to be worthwhilely recorded. Why should it?

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antipodean1
1 August 2010 2:39AM

@rpclarkeuk

the human mind does not have room for a 1000 years of experience to be worthwhilely recorded. Why should it?

So what. I am in my forties and it seems like i have forgotten more than i can remember already. Thats what computers are for! I have lots of digital memories now which is great.
Living longer will doubtless present lots of challenges for which we are not ready.
However I would love to experience some negligible senescence.
I realise thats a bit selfish though.

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farfrom
1 August 2010 2:44AM

The deletion of memories would seem to occur.

My wife has learned to drive a standard shift several times but it's gone in 6 months. I don't know whether new memories have replaced the the leartning.

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NapoleonKaramazov
1 August 2010 2:51AM

Humans are the only creatures that are so aware of their mortality that they are taught about death as soon as they are old enough to communicate. This knowledge effects our psychological health and personal behaviour unto the grave, and, is the cause of all religious motivation, reckless endeavour and subjective reasoning.

Suppose we really can extend life from a molecular biological basis- are people still going to get run over by car, will trains crash, will planes occasionally fall out of the sky? Of ocurse they will and people will die. The only way for these bio enchanced people to guarantee survival is to live in a hermetically sealed chamber- that would have an extremly negative effect on a person's mental health.

What's more, if people are really taught that they will not die, they will get a much more greater psychological shock when inevitably someone does die- getting run over by a car for example.

Arguing that our knowledge of our mortality affects our psychological health is undoubtedly true, but it would be much worsley affected if we were falsely led to beleive we are immortal.

Without a religion, or a developed philosophy of life, procreation would not continue the species line; humans would shun bearing children as their children's lives must ultimately end in tragedy - this is the hidden reason you find so many childless couples among the intelligensia. The same reasoning applies to keeping pets, who usually live far shorter lives than humans; investing empathy in an animal that one day must die is setting oneself up for an emotionally damaging future event.

Plenty of atheists still have children. There are plenty of non intelligenstia who do not have children. There are plenty of religious people who do not have children.

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Novelist
1 August 2010 3:43AM

So long as Gordon and Tony don't get any magic elixir of life.
Oh no! I just realised - Tony already gets his supply from Cliff.

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Novelist
1 August 2010 3:47AM

http://www.guardian.co.uk/users/rpclarkeuk

Basically the human mind does not have room for a 1000 years of experience to be worthwhilely recorded. Why should it?

- That's what 420 is for, fool!

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epinoa
1 August 2010 4:07AM

Ach, aging is just peer pressure.

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Elzadra
1 August 2010 4:50AM

Does anyone believe that anti-aging therapies will be handed out to everybody? Nobody seems to ask De Grey this question. The techniques will, at least at first, be very expensive, while also being experimental and borderline dangerous. But gradually we'll notice that certain very rich people are staying young and healthy for an awfully long time and it doesn't seem to be all down to plastic surgery. This could be the real class division of the future.

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Irina777
1 August 2010 6:39AM

When I was reading the article I asked myself a question "Do I want to love so long?" Of course, no ! People are getting older, because they are very tired of living. The older person becomes the more bored the life....

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Irina777
1 August 2010 6:42AM

Sorry, I wanted to write "Do I want to live so long?"

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rerab2
1 August 2010 7:31AM

It won t be much fun being 1000 - or even 21 - as the environment degrades, population rises, water and food become scarcer, energy shortages make life unbearably hard, society breaks down etc. It will be the Ik again - writ large.
The lucky ones will be the dead,

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PendulumAntiquity
1 August 2010 7:34AM

I'll wager there's more chance of extending life translating the knowledge in the brain to another medium. The body's a fragile container, evolutionarily expendable, processing biomatter for energy a gurgling stinky business, incurring periods of immobility. Plus, we want upgrades!

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thigham
1 August 2010 7:54AM

Oh god not Aubrey de Grey again! This man just forever talks about living forever, he's done nothing as far as I know to actually make it happen. It's such a ridiculous idea anyway, the world is full enough of people without having them all live forever. At the rate we are going the world is not going to be a place one would want to live eternally in anyway. The planet is slowing dying because of us. Hanging around with Aubrey and few other geeks as it finally reaches the end is not a proposition I for one welcome.
He should cut his beard too.

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freeword
1 August 2010 7:55AM

Alright then, let's get things straight.
Our bodies will be able to take a 1000 odd years, so will our brains or auxiliary systems to aid memory recollection, and then we can live happily ever after. And what about love and procreation, newborns coming into the world and increasing the population, feeding, dressing, housing the whole lot, and all that goes with it, like education, law and order.
It would bring about a whole revolution in humanity, in all aspects to say the least. So, when the planet does not contain us any longer because we would not have solved the moral problems of love and procreation, we would have to go deep into the sea, or underground, or colonise the solar system, or send traffic wardens around space to control massive spaceships making the rounds of our system.
The micro reorganisation of our cell system would necessarily bring about a macro revolution in our social order which no government, or world ngo, would be able to handle. To counter Dr Aubrey de Grey's cell manipulations we would just as well need other doctors in futurology to offer solutions for all problems being created? Anyone around... to start from down to earth current problems first before passing on to the apparently unfeasible?

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Clunie
1 August 2010 7:55AM

Irina:

People are getting older, because they are very tired of living.The older person becomes the more bored the life....

Eh? I hate to break it to you, but we don't get an option on the getting older thing - well, unless one counts death, which is rather terminal really.
As far as I'm aware, Aubrey de Grey wants to greatly slow down rather than actually stop the ageing process (and I'm sure if he were successful that our descendants a few hundred years hence will just love him and the other rich, greedy buggers who hang around for centuries to use up far more than everyone else's share of the ever-scarcer resources). But I think you'd need to stop time to actually stop age.

And it very much depends on the person on whether their life is boring or they are boring/bored - the two often go together anyway (and I've met bores of every age - there are plenty of super-narcissistic teen 20, 30, 40-somethings who'd give Aubrey de Grey a run for his money in the tedious self-obsession stakes). Doris Lessing and John Le Carre, meanwhile, are both getting on a bit and I sincerely doubt either of them could be boring company and just hope they hang around a few more years and keep writing - we fans a few decades younger would give our eye teeth for a millionth of their talent in youth or age. Also depends on one's definition of boredom.

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Greysquirrel
1 August 2010 8:07AM

Won't 1,000 years become the new 100?

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Clunie
1 August 2010 8:09AM

Was just thinking that it would be nice if Aubrey (his parents must have hated him) would take his head out of his no-doubt peachy youthful arse and check out the infant and premature mortality figures outside Western nations before making idiotic statements about how we ''more or less eliminated infant mortality.''

Perhaps when humans have managed to do so globally and there aren't nations where at 47 Mr. de Grey has already exceeded the average age for life expectancy by ten years (or by around 16 years, in Swaziland's case) , the whole idea won't sound quite so grotesquely narcissistic and adolescent; ''Don't wanna grow up, wanna live forever; I'm too good/special for death, me, death's for proles."

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Anarcher
1 August 2010 8:10AM

What will be the retirement age?

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azzeebeenin
1 August 2010 8:16AM

Aren't we all confusing eternal life with eternal youth which is the more preferable..

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Aussieinexcelsis
1 August 2010 8:49AM

What purpose could there be in a 1000 years of existence?: Perhaps Mahler may have finished his tenth and his eleventh and maybe Beethoven might of written a tenth and an a 78th (the mind boggles) and Keats may have got old and experienced middle age and Hendrix might have become what?

Your dearly missed Mum and Dad, your tragically taken children, your cancerous wife/partner...the list goes on and on.
Three score and ten looks positively minuscule in comparison but if anyone seriously thinks that a life spent in an eon of youthful bliss and shenagins is somehow missing what lifes about.

There is something quite tantalising about entering into that period of time when your chances of dying are far far better than when your young, it adds a certain (damn I know the French have a term for this) spark, a kind of second guessing about whether you should really bother going through the hassles of doing something that's slightly long term (like investing your money to spend in your latter years).

Come Mr Reaper and attend me at my annointed time.

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muppetteer
1 August 2010 8:50AM

What would people actually do, all day, every day, if they lived to 1000?

We already retire with about 30% of our life span ahead of us if you're lucky and live in a first world country... and even then, aside from getting up, planning the day around meals and going to bed, not that much actually happens for the average person... imagine centuries of that... day time TV would have to get a lot better for sustained life on that scale...

And isn't time relative? I remember talking to my grandmother who at 90, said that time goes so fast...

To anybody over the age of 30, the 6 week school holidays used to last forever when you were 7... now, 6 weeks seem to pass in the blinkmof an eye... i can't imagine how fast time would appear if I got to 300...

Scary stuff... Not sure it's for the best...

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RedRoseAndy
1 August 2010 9:11AM

Wanting to live forever is not as important as wanting to feel young again in most people's minds. The Kadir-Buxton Method is capable of doing just this. When the Queen Mother was in her seventies she told me in conversation that she would pay £1 million to feel 21 again. I performed the Kadir-Buxton Method on her, and the Queen Mother then said that she felt like a 24 year old. So near but so far!

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M0nkeym0n
1 August 2010 9:15AM

I can see it now, the television charity appeal of the future. "People are not dying anymore, we need to do something now..."

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martinique
1 August 2010 9:48AM

Have you ever noticed that the more time you have to do something, the more you put it off?
The despair (for most of us) of realising one's essential mediocrity (or would we all be geniuses, and what would that mean?), combined with loss of memory -or even worse endless technologically extended memory - and increasing indifference - all this prolonged indefinitely....
Ever read Huxley's Time Must Have a Stop? Even the 10th chapter of Gulliver's Travels? "Otherwise, as avarice is the necessary consequence of old age, those immortals would in time become proprietors of the whole nation, and engross the civil power, which, for want of abilities to manage, must end in the ruin of the public." Recognise this? We already have immortality in the form of corporations, which even possess personhood according to American law, which defines us all, as you know. And if you object that technological advance would keep people forever young: a whole society of adolescents? Eeuw.
And how much great literature would become irrelevant - "But at my back I always hear/ Time's winged chariot hurrying near" - and our lives thus impoverished. We already have the ghastly sub-reality of endless radio & TV serials to remind us of endless triviality. Aging is shit. But the alternative...

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ptah
1 August 2010 9:52AM

What is the objective here. To live to a prescribed age - say 1000 years without any suffering or illness and then just ... not wake up anymore? To live on and on getting slower and slower but never experience suffering? To live like a 27 year old for ever - whizzing around with the joy of life?

I don't get what he wants to achieve. The idea of reducing suffering is always going to find support but to pander to adults who don't want to grow up and live with the consequences of their actions is naive.

The research is probably very interesting but it seems to be an elite branch of science which will offer the rank and file of society little benefit.

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ptah
1 August 2010 10:00AM

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sminky
1 August 2010 10:21AM

when we're born, we're created from the earth's bank of molecules. then when we die, our molecules go back into the earth. we never really cease to exist, we're just re-distributed into new forms, both living and non-living.

the really interesting bit is the inbetween bit that we're all in at the moment. this life. it's what we do with it that matters, not how long we're doing it for.

on a personal basis, i'm trying to appreciate it as fully as i can. trying to see as much of what's going on around me and trying and learn something while i'm here.

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PaulBowes01
1 August 2010 10:35AM

Is this the biggest health crisis facing the world?

Absolutely. If we look at the industrialised world, basically 90% of all deaths are caused by ageing.

So we begin by ignoring everyone living outside 'the industrialised world'. Presumably it's okay for them to go on dying from preventable diseases and the effects of remediable poverty while de Grey encourages us to waste resources pursuing a selfish fantasy.

@Clunie gets this right: "grotesquely narcissistic and adolescent".

That doesn't mean that he won't find plenty of supporters, since 'narcissistic and adolescent' pretty well defines our culture.

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UweEllinghausen
1 August 2010 10:38AM

And you get married at age 250 and live for another 750 years with a nagging wife? No, thanks a lot.

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dormant
1 August 2010 10:42AM

The cost will not be prohibitive.

just take out a loan, repayable over 1,000 years.

And hope they raise the retirement age a tad.

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Rantalot
1 August 2010 10:51AM

Imagine how jaded and boring people would be after say 500 years .

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dinky1201
1 August 2010 11:06AM

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dinky1201
1 August 2010 11:08AM

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therealrodhull
1 August 2010 11:11AM

Basingstoke
1 Aug 2010, 2:04AM

He has not discovered or invented anything that could actually help us to live longer, so what exactly is the point of him?

The whole 'point' of him is to come up with the daft ideas that we don't need. In fact, so daft is his idea that as we have 6.5billion people on the planet (along with an already costly ageing population), thinking of ways to increase this number will actually do us more harm than good!

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Sessile
1 August 2010 11:15AM

The English dream. A world without kids.

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dholliday
1 August 2010 11:52AM

humans would shun bearing children as their children's lives must ultimately end in tragedy - this is the hidden reason you find so many childless couples among the intelligensia.

That's the funniest thing I've read all day.

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garetko
1 August 2010 11:52AM

Life should be about quality not quantity, much like beards

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HandandShrimp
1 August 2010 11:54AM

If we could get 500 year mortgages just think what it would do to property prices ;)

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lumpenfolk
1 August 2010 12:26PM

The population of the planet has almost doubled in my lifetime.

Although de Grey is not suggesting that everyone should be eligible for such treatment, it's interesting to think of the consequences.

Friday, August 20, 2010

Chronic pain? Slow but sure taiji may be the way Study finds it beats stretching exercises BOSTON: The slow, flowing movements of taiji are better at

Chronic pain? Slow but sure taiji may be the way
Study finds it beats stretching exercises

BOSTON: The slow, flowing movements of taiji are better at relieving pain and other symptoms of fibromyalgia than conventional stretching exercises, according to a study published on Thursday in the New England Journal Of Medicine.

A clinical trial at Tufts Medical Centre found that after 12 weeks of taiji, patients with fibro-myalgia, a chronic pain condition, did significantly better in measurements of pain, fatigue, physical functioning, sleeplessness and depression than a comparable group given stretching exercises and wellness education.

Taiji patients were also more likely to sustain improvement three months later, the report said.

'It's an impressive finding,' said Dr Daniel Solomon, chief of clinical research in rheumatology at Brigham and Women's Hospital in Boston, who was not involved in the research.

Although the study was small - 66 patients - several experts considered it compelling because fibromyalgia is a complex and often-confusing condition, affecting five million Americans, mostly women, according to the Centres for Disease Control and Prevention.

Since its symptoms can be wide-ranging and can mimic other disorders, and its diagnosis depends largely on patients' descriptions, not blood tests or biopsies, its cause and treatment have been the subject of debate.

'We thought it was notable that the New England Journal accepted this paper, that they would take fibromyalgia on as an issue, and also because taiji is an alternative therapy that some people raise eyebrows about,' said Dr Robert Shmerling, clinical chief of rheumatology at Beth Israel Deaconess Medical Centre in Boston.

'Fibromyalgia is so common, and we have such a difficult time treating it effectively. It's defined by what the patient tells you,' he added.

'It's hard for some patients' families and their doctors to get their head around what it is and whether it's real. So, that these results were so positive for something that's very safe is an impressive accomplishment.'

Fibromyalgia is estimated to have affected nearly 200 million people worldwide.

Recent studies have suggested that taiji, with its slow exercises, breathing and meditation, could also benefit patients with other chronic conditions, including arthritis.

But not all of these reports have been conclusive, and taiji is hard to study because there are many styles and approaches.

The fibromyalgia study involved the yang style of taiji, taught by a Boston taiji master, Mr Ramel Rones. Dr Solomon and other experts cautioned that bigger studies with other masters and approaches were necessary.

Still, patients who received twice-weekly taiji classes and a DVD to practise with 20 minutes daily showed weekly improvement on an established measurement, the Fibromyalgia Impact Questionnaire, improving more than the stretching-and-education group in physicians' assessments, sleep, walking and mental health.

One-third stopped using medication, compared with one-sixth in the stretching group.

Dr Chenchen Wang, a Tufts rheumatologist who led the study, said she attributed the results to the fact that 'fibromyalgia is a very complex problem' and 'taiji has multiple components - physical, psychological, social and spiritual'.

NEW YORK TIMES, REUTERS

Chronic pain? Slow but sure taiji may be the way Study finds it beats stretching exercises BOSTON: The slow, flowing movements of taiji are better at

Saturday, March 27, 2010

msm

Natural Health and Longevity Resource Center

Sulfur (MSM)

A Basic Essential Nutrient Needed Now, More than Ever Before

Methylsulfonylmethane is a relatively new dietary supplement form of sulfur that is found in our living tissues. MSM supports healthy connective tissues like tendons, ligaments, and muscle. Thus, it is important in conditions such as arthritis, muscle pains, bursitis, etc. MSM should be considered an integral part of any health care practice because of its physiological action, indirect importance, and current / future uses.
To understand MSM, some background information is necessary. MSM is a "naturally-occurring nutrient found in normal human diets" (1). It gets into the diet through the sulfur cycle. Ocean plankton release sulfur compounds which rise into the ozone where ultra-violet light makes MSM and DMSO. DMSO, dimethyl sulfoxide, is a precursor to MSM. MSM and DMSO return to the surface of the earth in rain (1). Plants concentrate MSM and return it to the earth and the sea. Evaporation into the air results in their return to the earth (1).
MSM has a unique action on body tissues. It decreases the pressure inside the cell. In removing fluids and toxins, sulfur affects the cell membrane. MSM is an organic form of sulfur, whereas sulfites in foodstuffs are inorganic. Sue Williams states "sulfur is present in all cells" and is in the form of "organic compounds throughout the body’ (2). However, sulfur can be found in the body in sulfate forms. It forms sulfate compounds with sodium, potassium, magnesium, and selenium. MSM has a significance, because sulfur compounds are found everywhere throughout the body and in nature.
Sulfur has an indirect importance, because sulfur compounds play a role in many body organs and systems. Sulfur is in the hair, skin, and nails. Many amino acids, the building blocks of protein, have sulfur as a component. Taurine is a sulfur-containing amino acid formed from methionine (2). Taurine stabilizes cell membranes (2). Methionine contains sulfur, detoxifies cells, and is involved in pain relief (2). Carnitine comes from methionine and transports long chain fatty acids preventing accumulations of lipoproteins (2). Many B-complex vitamins interact with or contain sulfur. Sulfur is needed for insulin production.
One current use of MSM is for joint problems, as sulfur is found in and near osseous structures. Sulfur supports healthy muscles, tendons, and ligaments. Arthritic conditions have responded to oral MSM. Some researchers note results from MSM when used for post-exercise muscle pain (1). MSM normalizes pressure inside cells and removes toxins. Oregon Health Sciences University has conducted arthritis studies with mice. The mice which received MSM had "no degeneration of articular cartilage" (1). The other non-MSM mice had cartilaginous degeneration. The university has used MSM on over 12,000 patents. Researchers make no claim about MSM as a supplement, but osteoarthritis, rheumatoid arthritis, muscle soreness and muscle pain respond to oral MSM.
One researcher claims MSM is about as safe as water. One should drink extra water with MSM use. There are other dietary factors to consider.
Avoiding nightshade plants has helped arthritis patients (tomatoes / potatoes / green pepper/eggplant). Biotin and vitamin C help the body assimilate MSM. Biotin and vitamin C are found in fresh fruits. Eating fresh fruits while taking MSM could be helpful.
In addition to arthritis, it may have other future uses. Dr. Stanley Jacob believes ,'most people are deficient' in sulfur (1). Insulin synthesis depends upon sulfur. Many vitamins require or contain sulfur. Some researchers claim it has many future uses such as in allergies (1).
A good MSM product is both safe and effective. The MSM source for MSM supplements is often lignin from pine trees. Lignin is a molecule in plants that is part of a plant's cell wall. Lignin oxidation in oak wine barrels results in the vanilla flavors of wines. The pine tree lignin is an ideal source for a good MSM product.
For those who do not want to take MSM as a supplement, food sources of sulfur are as follows: sunflower seeds, garlic, lentils, soybeans, and yogurt. Persons with kidney problems or recurrent kidney stones may not want to take MSM. Certain renal tubular defects can make a person susceptible to recurrent kidney stones (2). Other kidney defects include errors of metabolism in which processing of sulfur amino acids is altered (2). Such persons may wish to avoid MSM.
One thousand to three thousand milligrams per day is a typical dosage range, but some people take well above that amount. This author takes MSM alone.
From the cell walls of pine trees to the cells of the human body, a good MSM supplement can contribute to good health.

Conditions That Have Reportedly Responded to MSM Supplements

Sunday, March 7, 2010

What does the Organic Germanium do to humans?

GERMANIUM
The following links provide the basis of Germanium and its properties, applications and uses.
ARTICLES:.

"The Missing Element: Organic Germanium"
http://www.stopcancer.com/germaniumstor.htm

"Miracle Cure: Organic Germanium" by Dr. Kazuhiko Asai
Dr. Kazuhiko Asai published this famous book on Germanium in 1980, it was published by Japan Publications and was out of print by 1989. This page is the equivalent of 47 pages in a Word document.

Organic Germanium as A Treatment of Cancer

Chemical Name - bis-carboxyethyl germanium sesquioxide.

Germanium in its inorganic form, is widely used in the electronics industry as a semiconductor, and has no nutritional or healthful effects on humans. However, Germanium in its organic form has been acclaimed as one of the most outstanding new developments in the treatments of cancer.

Organic germanium can stimulate the body's immune system and enables the body to change its response to tumors. Because cancer cells multiply at a furious pace, their "electric potentials" are high and undergo extremely rapid cancer cell development. Germanium lowers the "electric potentials" of cancer cells by taking away their electrons. This, in turn, suppresses the activities of abnormal (cancer) cells and also keeps cancer from spreading violently.

Organic Germanium is a trace that enhances the availability of oxygen to both cancer cells and healthy cells. It is well known that cancer cells cannot grow vigorously in an oxygen-rich environment. Germanium has a remarkable ability to stimulate the immune system in cancer patients as well as healthy people.

What does the Organic Germanium do to humans?

• It normalizes blood pressure.
• It boosts the immune system.
• It protects the body against harmful cellular abuse and abnormalities.
• It relieves rheumatoid arthritis symptoms.
• It generally normalizes physiological

functions and provides some pain relief.
Dr. Kazuhiko Asai was intrigued by the high concentrations of germanium in coal as he himself worked for the Coal Research Institute (CRI). Dr. Asai theorized that germanium could be present in plants, since coal is composed of fossilized plants.

He found that the highest concentrations of germanium were found in these plants that are used for medicinal purposes:
• Shitake mushrooms
• Ginseng
• Aloe
• Garlic
• Comfrey
• Shelf fungus (highest level of germanium found)
• Chlo

Treatment with organic germanium

Future Trend in Medical Treatment -
Inducement of the Body's Natural Healing Power

The other day I had an interesting conversation with a friend now living comfortably in
retirement. This friend had earlier been successfully treated with my organic germanium
compound and had become a firm believer in its efficacy. For many years he had been from
had been ringing in the ears, and although various medical cures had been attempted, he had
gained little relief. Treatment with organic germanium, however, completely healed his ailment,
and furthermore, his general health showed a most remarkable improvement. In fact, one
would hardly suspect that this healthy gentleman had already lived over 70 years, Borne out
of a philanthropic spirit and on the basis of his own experience, he decided to use my organic
germanium Compound (without infringing on any pharmaceutical regulations) to help other
people suffering from incurable diseases. Not surprisingly he has been a very successful in his
efforts, much to the gratitude of' large number of people.

My friend had this to say. "Rather than being similar to modern is more pharmaceutical
medicines. this organic germanium compound like one of the traditional Chinese medicinal
herbs. I have used it to treat a number of different illnesses, and have found its healing effect
to be more constitutional than allopathic that is, it acts on the body as a whole rather than on
any specific symptom. "To put it more simply, your organic germanium cures diseases by
inducing the body's own natural healing powers. I am convinced that by increasing the flow of
oxygen, organic germanium stimulates latent natural healing powers existing in the human
body, thereby resulting in a very effective cure of any illness."

From the way in which various diseases had been cured by organic germanium treatment,
I too, had become aware of a rather close link between the action of organic germanium and
natural healing processes in the body. However, at that time, I had very little idea of just what
these healing powers were, or how they were to be described in scientific terms.

Another interesting visitor came to me some time afterwards, this time an elderly medical
practitioner who had become familiar with acupuncture. He told me that the scientific
principles behind acupuncture anesthesia had recently been brought to light, and that more
conventional pain suppression anesthetics, such as morphine etc. will no longer be needed in
surgical operations. Furthermore, he continued, patients can be relieved of pain for up to 27
hours and suffer no side effects. Postoperative progress of the patient also seems far better
than after the use of conventional anesthetics.

In brief, recent research has shown that when acupuncture needles are applied to what are
known as tsubo in Oriental medicine, the pituitary gland secretes a peptide hormone called
beta-endorphin (which consists of 91 amino acids in a 61 to 91 amino acid sequence)
resulting in a strong pain suppressing effect. The tsubo vary according to where the operation
is to be performed. Three acupuncture needles are inserted precisely at the required
positions, and after 15 to 20 minutes the desired anesthetic effect is achieved. Since the
anesthetic agent is an autogenic anesthetic produced in the body, there are no undesirable
side effects, and postoperative recovery is rapid. However, the doctor continued to say that
since these tsubo and other facets of acupuncture are not acknowledged in Western medicine
and are not included in university medical courses, this excellent anesthetic practice is not
generally employed.

It dawned on me as I listened that this anesthetic action is very similar to the action of my
organic germanium compound. On being given 3 to 4 grams of organic germanium cancer
patients literally writhing in pain have found relief in 15 to 20 minutes. Time and time again, I
have witnessed terminal stage cancer patients find release from their torment as if by magic,
and be allowed to finally pass from this world in peace.

Pain is a form of warning passed from the troubled area to the brain by means of an
electric charge relay mechanism along nerve cells. It is only "signal" reaches the brain that we
actually feel pain. Anesthetics. such as morphine, prevent us from feeling pain by interrupting
this electric charge relay temporarily by chemical action.

Germanium. on the other hand was initially thought to interfere with the electric charge
relay process due to its semiconductor properties. and this action quite possibly takes place.
However , it also seems reasonable that the introduction of a pseudo morphine anesthetic
agent called called "endorphin is stimulated in the body by germanium in much the same way
as by acupuncture needles. This proposition is certainly supported by the results of
experiments on laboratory animals using organic germanium. The color and luster of hormone
secreting the thyroid and adrenal glands are considerably improved, while the animals' hair
becomes glossier, giving the animals a rejuvenated appearance.

In clinical cases, too, germanium has been very effective in the treatment of a number of
diseases caused by adrenaline inadequacies, including enlargement of the prostate gland,
cancer of the breast and uterine cancer, goiter and uterine mvoma, etc. It would thus appear
germanium compound has a kind of electro-biochemical action quite unlike the effect of
conventional pharmaceuticals. For example example, germanium increases the amount of
oxygen transported by hemoglobin in the red blood cells. The supply of oxygen to tissue cells
is thereby increased. resulting in greater cellular activity. This in turn can be assumed to be
responsible for various other biochemical processes in relation to cell membrane potential.
The pseudo morphine agent "endorphin" referred to earlier is a peptide hormone secreted
from the hypothalamus in the brain, and is thought to be stimulated by the germanium
compound.

To think that Oriental medicine that has its origins some 3,000 years ago discovered an
anesthetic procedure, which has now been substantiated by modern science, is exhilarating to
say the least! I can only marvel at the wisdom of the ancient Chinese and the systematic
development of their knowledge of medicine.

At present, however, the focus of world attention has been turned to the "wonder
medication " interferon. The existence of this substance was first brought to light more than 20
years ago, and is considered one of the most significant medical discoveries since penicillin,
particularly where cancer treatment is concerned. However, just what kind of substance
interferon is, and how it works, remain very difficult questions to answer.

To put it as briefly as possible, when an infectious virus enters the human body, tissue cells
commence to secrete interferon (a glycoprotein with a molecular weight of about 40,000) to
protect the cells from the viral infection. In addition, there is also an increase in the number of
macrophages (one of the leucocytes involved in the removal of cells) for greater effectiveness
against cancer cells.

Clinical test with interferon have produced excellent results. So much that pharmaceutical
manufacturers have started to worry that that their more conventional products will become
obsolete. It should be noted here, however, that interferon is not a new drug - it is a
substance produced in the human body, whose natural healing powers have been harnessed
scientifically.

That famous doctor Robert Koch is quoted as saying, "The best substances formed
naturally by the human medicines are those body." It seems he was forecasting the discovery
of interferon, Although was discovered, and its significance understood, more than 20 years
ago, there are several reasons why it has not been used greatly. First, large scale cell cultures
are required which are very difficult to grow. Secondly, since the amount of interferon
obtained is very small, little has been learned about its chemical structure. Although it has
been found to be a glycoprotein, its molecular sequence and its biochemical action in the
human body have still not been studied sufficiently, Thirdly, nothing is known about how
interferon is produced in the cells, and fourthly, interferon is unbelievably one gram costing
more than $100,000.

At present, this wonder working substance, interferon, has still not been synthesized in the
test tube. Only live cells are capable of its production, and furthermore, the only interferon
which is effective in the human body is that which is produced by human cells.

As the synthesis of interferon is practically impossible, and there seems little likelihood of
any suitable method for production being developed in the near future, it has been proposed
that the same result might be obtained by somehow inducing the production of interferon from
living cells in the human body. Consequently, a number of researches have attempted to
force the secretion of interferon by stimulating the cells with various toxic substances.
However, although this method does in fact stimulate the cells to secrete interferon, the
stimulating reagents are invariable toxic, and cannot be used for medical purposes.

During my own research. I have often paid attention to matters relating to the electric
charge on cell membranes. Apparently the very nature of cancer cells, for example, is
changed by alterations in the cellular membrane potential. Nobel prize winner Prof.. Albert
SzentGyorgyi has put forward similar ideas based on electro-biochemical concepts. My
germanium compound is an organic compound containing atoms of the semiconductor
element germanium. The semiconductor property of the germanium atoms enables this
compound to bring about changes in electric charge ( as can be seen in the dehydrogenation
and super oxidation effects.)

From the above suppositions it is postulated that it is this change in membrane potential of
the cancer cells that results in the stimulation of interferon production. Supporting evidence
for this postulation is presented in the accompanying diagram.

Throughout this book I have explained the basis of an organic germanium compound
exhibit solely on the basis of an increase in the amount of circulating oxygen in the body. This
explanation, however, is inadequate. To be sure, the dehydrogenation effect in the body is
certainly an advantage in various medical treatments. However, with the discovery of the
induced production of such a powerful weapon as interferon in the suppression of diseases
and particularly the elimination of cancer cells. I felt an overwhelming sense of conviction that
I was moving closer to the truth.

Modern Western medicine is based on an allopathic approach (i.e. treating symptoms as
each calls for attention.) Cancer resistant agents are typical examples, but these agents
involve undesirable side effects resulting in the considerable recent controversy about
iatrogenic diseases (diseases caused by medical treatment.)

I think it would be quite proper to call interferon a "natural healing substance," In contrast
to anticancer agents, interferon is produced within the body in order to protect the body
from disease, It is designed to support life, and does not, therefore, result in any undesirable
side effects in other parts of the body. Furthermore, my organic germanium compound,
which induces the production of interferon, is also completely nontoxic and free of side
effects. In this sense, it is very similar to traditional Chinese medicines.

Another interesting fact which should be considered here is that just as acupuncture fails to
affect some people (i.e., no anesthetic action) germanium, too, on rare occasions fails to
induce the secretion of any quantity of interferon. Although the reason is not easy to explain,
my observations of clinical cases where organic germanium has been employed tends to
make me believe that this phenomenon is due to acidosis of the blood which is a result of loss
of a proper acid/alkaline balance.

I would like to state my belief that the induced production and secretion of interferon by
organic germanium, and of endorphin by acupuncture, establishes a scientific basis for
Oriental medicine. Chinese medicinal herbs invariably contain high levels of germanium. and
furthermore, it is also possible that these herbs also contain other compounds that induce the
production of other interferon like substances in the body.

In acupuncture, stimulation via the tsubo results in the increased production and secretion
of endorphin which in turn results in a healing effect. In moxa cautery treatment, the toxic
components resulting from the thermal decomposition of protein under the scorched portion
of skin are passed into the bloodstream, and subsequently induce the production of interferon
in the tissue cells. Both endorphin and interferon are types of hormone, each closely related
to the other. Living beings have been endowed with these natural healing substances for self
preservation purposes.

I believe future medical treatment will be centered around the use of these and similar
substances. The basic concept is expressed as "Sho" in Oriental medicine, "Gesamtheit" in
German, and "holistic" in English. On this basis, the amount of circulating oxygen which is so
essential to life is increased to strengthen the body's defense against the cause of a disease,
and the production of the powerful weapon interferon is also increased to join in the fight
against the pathogen.

ABOUT GERMANIUM

A. HOW YOU FEEL PAIN
There is no such thing as pain if it doesn’t reach the brain. When a pain impulse is initiated, it must reach the brain to be determined as pain. Our illustration to the right exemplifies this concept.

The nerve impulse is carried to the brain in a manner that is similar to the flow of electricity along a wire. Simplified, the pain impulse is transmitted to the brain via a flow of positively charged magnetic particles called ions.

There are several ways to block the transmission of the pain impulse to the brain. One is the use of an anesthetic block. A second is the use of drugs which act on the hypothalamus of the brain to dull the pain. The third is the use of Ge-Ti-Magnet-Minus Ion Therapy to impede the flow of the nerve impulse.

By placing a highly powerful negative magnetic field over the nerve, the magnetically, positively charged ions will be attracted to the negative magnetic field, thus impeding the flow of the positively charged ions along the nerves to the brain. Of course, some of the positive ions will escape, thereby allowing continued sensation. However, our research reveals that the longer the magnets are in place over the affected site, the more effective the negative magnetic field will become, Thus, the longer the product is used, the more effective it becomes.

On the basis of this research, Dr. Bakst applied for and received the only magnetic concept patent in the United States (U.S. Patent #5707333).

B. ABOUT GERMANIUM
Germanium allows anion(outer electronic) to be fast absorbed in the body in case of being touched the skin, due to its semiconductor attribute,and functions as incrersing the vitality of skin. Also, incase of entering the inside of the body,it is discharged outside the body within20~30 hours together with harmful substance, thus there is no poisoning or side effdct at all.

If a particle of germanium comes to contact with the skin of a person, the semiconductor attribute enters the inside of skin tissuce due to the osmometry activity of outer electronic. Germanium, which infiltrated up into the capillary vessel inside the subcutis, moves the electronic in the blood wall, normalizes the blood due to the function of purifying blood, and allows a pain to be avoided by discharging the excessively electronic flow.

C. ABOUT TITANIUM
Titanium has the most bio-friendly characteristic among all metals such as the resistance to physiologically rejection rejection phenomenon of body fluids,as well as high intensity and lowly modulus of elasticity.lts weight is light compared to iron and has no allergy or virulence enough to be used for medical equipment,thus being a metal that is excellent in bio-appropriateness and has specially electrical characteristic.

A role of titanium is in increasing conductibility of anion and far-infrared that occur in the added raw ore,thereby having faster influence on the human body.

D. ABOUT MAGNETS
Magnetic strength is measured in gauss. The higher the gauss rating, the stronger and more effective the magnet will be. Magnets can be compared to light bulbs. 40 watt bulbs do not shine as brightly as 100 watt bulbs. The same is true of magnets, the higher the gauss, the stronger the magnet will be.

The magnetic field has the ability to penetrate through the skin. Correspondingly, different magnets have different depths of penetration through the skin.

Our products are the only ones on the market that use strategically placed Germanium, Titanium, Non-rusting magnets, which makes our products superior and more effective than any other product on the market.(See graphs of penetration depth.)

E. PLACEMENT OF THE GERMANIUM,TITANIUM,NON-RUSTING MAGNETS & MANUS ION

Ge-Ti-Magnet-Minus Ion cannot simply be placed indiscriminately over an affected site. It must be placed so that they can reach the affected nerves. The placement over the affected site, and the material in which the Ge-Ti-Magnet-Minus Ion are placed are what make our products so unique and effective. Most products on the market do not take these factors into consideration.

Our products are carefully and scientifically prepared. Using the anatomy book to carefully document the position and course of the affected nerve, then carefully places the Ge-Ti-Magnet-Minus Ion in the scientifically appropriate position. In addition, the depth of the nerve is carefully measured and the appropriate magnet is used in that area. That is why we strategically place a considerable number of Ge-Ti-Magnet-Minus Ion in our products. Lastly, we use the highest quality neoprene available to add additional support to our products.

Our products are the only ones available on the market in which Germanium, Titanium, Non-rusting magnets, Minus Ion are used and strategically placed.

F. OUR PRODUCTS ARE THE BEST AVAILABLE
1. It is the only magnet product with Germanium, Titanium,Non-Rusting Magnet,Minus Ion.

2. All products have ions strategically and anatomically placed by Ge-Ti-Magnet-Minus Ion to maximize proper placement, polarity, position, penetration and power.

3. Only our products contain and use Ge-Ti-Magnet-Minus Ion for maximum pain control.

4. Our products maximize comfort and pain relief.

G. OTHER BENEFITS FROM GERMANIUM,TITANIUM,NON-RUSTING MAGNETS & MINUS ION

Ge-Ti-Magnet-Minus Ion also have been scientifically proven to have a profound effect on a basic cellular level. It has been demonstrated that they increase circulation to the area within the magnetic field. They increase tissue phosphorylization, which aids in fibroblast proliferation and the healing of tissue. It increases the level of alkaline phosphatase at fracture sites, which expedites healing of fractures. It affects the membranes of red blood cells, decreasing rouleaux formation and increasing oxygenation of tissue. There are a multitude of other salutary effects of Ge-Ti-Magnet-Minus Ion on a basic cellular level, which are just beginning to be appreciated. So, although Ge-Ti-Magnet-Minus Ion themselves do not heal an injury, they increase circulation to the affected area, thereby helping the body to heal more quickly.

Veterinarians have been using Ge-Ti-Magnet-Minus Ion to help alleviate pain and swelling in horses. Recently, a group of advanced orthopedic surgeons have begun to use Ge-Ti-Magnet-Minus Ion on fracture sites to expedite the healing of some of the more difficult fractures.

We continue to receive hundreds of letters from doctors, athletes and people of all professions who attest to the wonders of Dr. BOX’s Ge-Ti-Magnet-Minus Ion products. Almost everyone who uses our products have obtained relief from their pain. Our products are scientifically researched, designed and are highly effective.

For more inforamation please contact with me: SKYPE: globalesaler,MSN:globalesaler@msn.cn.MB:86-13611827612